Health And Medicine

Scientists Turn Off Genes That Spur Deadly Brain Cancer

Scientists at Northwestern University have discovered a small RNA molecule known as miR-182 that has the ability to quash cancer-causing genes in mice with glioblastoma mulitforme (GBM), an incurable and deadly type of brain cancer.

Scientists at Northwestern University have discovered a small RNA molecule known as miR-182 that has the ability to quash cancer-causing genes in mice with glioblastoma mulitforme (GBM), an incurable and deadly type of brain cancer.

Unlike standard treatment with chemotherapy drugs that stop cancer cells from reproducing which often results in damage of DNA, the new method implements sperical nucliec acids (SNAS) to safely deliver miR-182 across the blood-brain barrier to reach tumor cells. This way, it stops the expression of several oncogenes that encourage the development of cancerous cells. In short, the molecule miR-182 suppresses Bcl2L12, a cancer gene that prevents cancer cell from being eliminated by either chemotherapy or radiation therapy.

Also when researcher examined large-scale genomic datasets, they found that the patients with higher levels of miR-182 had a longer chance of surviving glioblastoma multiforme (GBM). miR-182 molecule is a short non-coding microRNA that binds to several genes to suppress their protein expression in cells. [Northwestern University ]

10 comments

  1. They have been using the Polio vaccine too with a modified DNA molecule of the common cold to make it work. This sounds more promising though. The Polio one has some pretty bad side effects.

  2. I can’t even pretend I understand any of this post, but anything that promotes the hope of curing this horrible plague on mankind is a wonderful thing!! Thank you for share some good news.

  3. Apoptosis was the idea of activating the self destruct gene in cancer and deactivating the survival gene. I read about it 20 years ago and it seemed very promising but seems a long way off for true effectiveness .

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